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Questions? call tech support @ # above. Montiff Information Page on Pure L-Histidine L-Histidine is an essential amino acid, which converts to histamine, a powerful blood vessel dilator, involved in gastric acid secretions and neurotransmission in the central nervous systems. It is also related to circadian rhythms and sexual arousal and orgasmic function in women & premature ejaculation in men. Low levels of L- Histidine have been associated with Rheumatoid Arthritis, and anemia.   Each capsule of Pure L-Histidine contains: 600 mg of the highest quality L-Histidine. DIRECTIONS: Take 1 to 3 three times daily a half-hour or more before meals with a full glass of water or fruit or vegetable juice. Vitamins and minerals are recommended for proper metabolism, especially B-6 and Vitamin C. Vita-Minz-Plus and B-Complete as well as Ultra C should be taken daily. For female sexual arousal and orgasms - 1 capsule T.I.D. prior to meals is suggested. CAUTION: Those with elevated Histidine or histamine levels should not take L-Histidine supplementation. These may include manic-depressives, those with schizophrenia, problems with chronic allergies, pregnant women or women with PMS. Individuals who have hypertension should exercise caution, and those with peptic ulcers and excessive gastric juices should avoid Histidine supplementation. RECOMMENDED TO ENHANCE STRUCTURE & FUNCTION RELATING TO: Functioning as a precursor to histamine Sexual arousal and orgasmic function Rheumatoid Arthritis Precursor to Carnosine and Anserine Gastric acid secretions to aid digestion Circadian rhythms Neuronal health and function Production of red and white blood cells WHAT IS L-HISTIDINE? L-Histidine is an essential amino acid important for growth and repair of tissues. It is necessary for the maintenance of myelin sheaths, which protect nerve cells, and the production of red and white blood cells. It is the precursor for histamine, and B-6, niacin, and Vitamin C are necessary for proper metabolism. It is also a precursor for Carnosine and Anserine. Histidine acts as an antioxidant protecting against radiation damage by helping to remove heavy metals from the body. It stimulates the secretion of gastric juices; therefore helping with digestion. Low levels have been associated with decreased hemoglobin and hematocrit, as well as those with Rheumatoid Arthritis. Deficiencies are also noted in Dysbiosis (an imbalance of intestinal flora) and anemia, and low levels may also attribute to nerve deafness. Excessive levels have been associated with psychological disorders such as schizophrenia and high levels are noted during pregnancy. In the diet, it is found in rice, wheat and rye. WHAT IS HISTAMINE? Histamine is a molecule that is a potent vessel dilator, important for sexual arousal and orgasm in women. It also acts as a neurotransmitter having an effect on the nervous system, and as a stimulator to the secretion of pepsin and hydrochloric acid, it is important for digestion. Several studies indicate that the histamininergic neurotransmitter system may be a regulator of circadian rhythms that function in the sleep and wakefulness cycle. Since L-Histidine is the precursor for histamine, deficiencies effect the histamine levels. When allergens are present, however, histamine is released from the mast cells causing inflammation, fluid production and possibly hives. (Antihistamines have been recommended for allergic problems.) SEXUAL AROUSAL and FUNCTION: Histidine is involved in the function of the thalamus and hypothalamus glands, and orgasm is triggered when histamine is released from the mast cells in the genitals. Histamine also causes the sexual flush that occurs during arousal. Many women fail to achieve sexual pleasure and orgasm, and often other treatments including psychotherapy may be unsuccessful. This problem may be a result of a biochemical imbalance, since sufficient histamine must be present in order to trigger an orgasm. Deficiencies of L-Histidine will effect histamine levels. Supplementing with L-Histidine will increase histamine levels as proved by Carl Pfeiffer, M.D., and Ph.D. in his research on non-orgasmic women. He administered doses of 500mg. of L-Histidine (1 capsule) before each meal (for a total of 3 capsules per day) restoring sexual pleasure in women. (He also helped women who had irregular periods become regular by giving doses of 4grams per day). Dr. Pfeiffer noted that males who had excessive L-Histidine levels had the problem of premature ejaculation. He gave these men supplementation of 500 mg. of L-Methionine (1 capsule) along with 500 mg. of magnesium and 50mg. of vitamin B6. This helped normalize the levels of Histidine, and alleviated the problem of premature ejaculation. Important note: Because of the dangers of Homocysteinuria those taking L-Methionine should never take more than one capsule/day & it would be better done against the background of a broad spectrum amino acid mixture (ALL-BASIC) (1-2 capsules) before each meal (for a total of 3-6 capsules per day)  also take a B complex with folic acid to help prevent excessive Homocysteine levels. (Take 2 Montiff B Complete daily - 1 in the morning and 1 in the evening to get sufficient folic acid and B 6.). RHEUMATOID ARTHRITIS: Low L-Histidine levels have been noted with those who have Rheumatoid Arthritis. This may contribute to the pathogenesis of this condition by causing hyaluronadate-augmented formation of aggregated synovial fluid gamma globulin. The gamma globulin aggregation thus causes the inflammatory and rheumatoid factors. Supplementation of L-Histidine may be helpful in some cases, although not always successful. In one double-blind study, patients were given 4.5 g daily. After 30 weeks some benefits were noted in those who had a long history of the disease.   REFERENCES: Maeda, K, Taniguchi H, Butterfield et al (First Dept. of Internal Med., Tohuku Univ School of Med.) "Induction of L-Histidine Decarboxylase in a Human Mast Cell Line", Exp. Hematol, 1998. Tuomisto, Leena, "Modifying Effects of Histamine on Circadian Rhythms and Neuronal Excitability", INABIS, 98. Pheiffer, Carl, MD, PhD, Mental and Elemental Nutrients, Keats Publishing, 1981. Gerber, D., and Gerber M, (Dept. of Med. - New York State Med. Center and Kings County Hospital), " Specificity of Low Free Sodium Histidine Concentration for Rheumatoid Arthritis", J. Chron. Dis., 1977. Pinals, R. et al, "Treatment of RA with L-Histidine", J. of Rheumatology, 1977. Tyson, Don, Amino Acids Metabolism and Analysis - Interpretation Guide, Aatron Med. Services, 1989. Balch, James, MD, and Phyllis Balch, CNC, Prescription for Nutritional Healing, Avery Pub., 1997.

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Glossary

Column

Amino Acids - Are the building blocks of protein. Your body is primarily made of protein.  And protein in turn, is made up of chains of amino acids What distinguishes all amino acids is that they all have a group, (amine group), made of 1 atom of nitrogen & 2 atoms of hydrogen. (NH₂)

Free-Form Amino Acids - Individual amino acids that are  unattached to each other or anything else & therefore able to be immediately absorbed into the blood stream with no digestion necessary. Since, unlike proteins, free-form amino acids require absolutely no digestion, they can be absorbed by anyone no matter how old they may be or the condition of their digestive system.  Also, unlike proteins, free-form amino acids can be taken on an empty stomach such as right before a workout.  Whereas proteins have to have a mass of food sufficient to stimulate the release of digestive juices. This is why most protein supplements are presented as blender drinks.  Free-form amino acids are not to be confused with so-called "predigested protein."

Negative nitrogen balance - The condition of excreting more amino acids & protein than one is taking in. This makes it difficult to maintain ones body since the body's tissues are mainly made of protein & amino acids which require constant maintenance & repair.

Precursors - the substance from which another substance is made.

Protein - Chains of some combination of the 20 so-called "proteogenic" amino acids. (proteogenic means to generate protein). In other words their are only 20  amino acids from which all proteins in all organic life both animal & vegetable are made. Not all 20 are in every protein, but nothing else but some portion of the 20 proteogenic amino acids in repetitive long chains often approx. 100,000 amino acids long are what all proteins in all life are made from.

Secretalogical cells - Cells that secrete hormones.