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Questions? call tech support @ # above. Montiff Information Page on: Pure L-ARGININE HCL - U.S.P. 500mg caps

RECOMMENDED TO ENHANCE STRUCTURE & FUNCTION RELATING TO NUTRITIONAL NEEDS AND DEFICIENCIES PERTAINING TO: Endothelial support for circulatory health. Promoting protein synthesis and anabolic activity for those with surgical stress, trauma, sepsis and catabolic conditions. Immune support. Urea cycle support. Anabolic response for athletic physique. For vascular health, and high blood pressure, Pure L-Arginine-HCL (Elemental) may be combined with Cardio-Care, Vaso-Lene and Cir-Cu-Care to increase nitric oxide production and maximize total endothelial support. Those with active Herpes (genital or “cold sores”), or elevated titers to the herpes virus, EBV, Mono or similar viruses should take additional Lysine to maintain the proper Lysine/Arginine balance of at least twice the amount of Lysine to Arginine ratio. To prevent biochemical competition of these amino acids, take Arginine approximately 1-5 hours prior to Lysine supplementation. Is important for a healthy cardio-vascular system. Promotes endothelial support for circulatory health. Is part of the urea cycle and is important in wound healing and the immune system. Makes up 80% of sperm and may be useful for infertility. May promote growth hormone Production in conjunction with Ornithine, and anabolic support for the athlete. Those with active herpes or elevated titers to the herpes virus, EBV, Mono or similar viruses should take additional Lysine to maintain the proper Lysine/Arginine balance of at least twice the amount of Lysine to Arginine ratio. WHAT IS ARGININE? Arginine is synthesized in the intestinal tract from Citrulline, and its major food sources are nuts, (peanuts, cashews, almonds, walnuts and pecans) although it is also abundant in chocolate, carob, and edible seeds. It is the precursor for Ornithine and is a vital part of the urea cycle, being involved in the detoxification and elimination of ammonia. It is also important for Nitric Oxide production, (necessary for endothelial health and vasodilation), protein synthesis, wound healing, immune function and has a secretalogical effect on hormones. Eighty percent of seminal fluid is made of Arginine, and it plays a role in the reproductive system of females as well. It is also a precursor required to synthesize polyamines, which are required for growth and function of all healthy cells. Those with Herpes and similar viruses should take additional Lysine to maintain metabolic Lysine/Arginine balance. Since it competes for absorption with Lysine, the Lysine supplements should be administered approximately 1-5 hours after Arginine supplementation. THE IMPORTANCE OF ARGININE AND NITRIC OXIDE: Nitric Oxide (NO), a small molecule synthesized from Arginine in the body, is the endothelial relaxing factor (EDRF). It plays an essential role in the regulation of vascular homeostasis, and modulates cardiac contractility, regulates vascular tone, and helps in preventing vessel injury and Arteriosclerosis. Studies at major universities support the importance of Nitric Oxide, and its role in the endothelial-vascular system of the body, as well as the effects of Arginine supplementation on normalizing high blood pressure levels and its potential to lower cholesterol and LDL levels. Recent studies suggest that damage from hypertension, high cholesterol and other coronary heart disease factors, impairs the ability of the endothelium to produce necessary Nitric Oxide. When plaque builds up, the blood supply to the endothelial cells gets blocked and also prevents the production of Nitric Oxide. After many years of plaque accumulation, Arteriosclerosis occurs. These recent medical studies suggest that Arginine supplementation can begin to reverse this process by helping to restore endothelial cells that have been damaged, and increase their ability to make Nitric Oxide. IMMUNE SYSTEM AND ARGININE: Arginine stimulates the production of polyamines, which are necessary for healthy cell function. It also appears to improve T-cell activity, and after just three days of Arginine supplementation, patients in one study were observed to have a dramatic improvement in T-cell mitogenesis with improved function of T-lymphocytes. WOUND HEALING, SEPSIS AND TRAUMA: Studies of Arginine supplementation with postoperative patients and those with sepsis and trauma have shown increased healing capacity due to improved immune function. Patients who were administered Arginine had a reduction in infections and experienced reduced hospital stays. ARGININE AND CANCER: Arginine acts as a free radical scavenger, and preliminary studies indicate it inhibits tumor induction by many carcinogenic chemicals. It may be due to immune function stimulation, including stimulation of T-lymphocytes, which are natural killer (NK) cells. The effect of Arginine in the production of polyamines may also be crucial. ATHLETES: Arginine stimulates both growth hormone secretion and insulin production, and has an anabolic effect on muscle tissue. The use of anabolic steroids by many athletes may result in hypertension and Hypercholesterolemia causing damage to the cardiovascular system. Arginine supplementation may create the athlete’s desired anabolic results without the negative effects on the cardiovascular system caused by these drugs. Since Arginine stimulates the production of NO (nitric oxide), supplementation may help reverse the endothelial damage for those who have been on steroidal drugs. BENEFITS OF MONTIFF PURE L-ARGININE- HCL (Elemental) Montiff supplies the highest quality, pure L-Arginine-HCL (Elemental, or active Arginine). L-Arginine-HCL, a stable molecular form of Arginine, helps provide hydrochloric acid, which is necessary for proper digestion. This prevents stomach irritation, which is possible with the “base” (alkaline) form of Arginine found in other many other companies’ products. REFERENCES: Cynober, Luc (edited by), Amino Acid Metabolism and Therapy in Health & Nutritional Disease 1995. Di Pasquale, M, Amino Acids and Proteins for the Athlete. the Anabolic Edoe, 1997. Latifl, Rifat, M.D., Amino Acids in critical care and cancer, 1994. Lowell J, Parnes H. Blackburn G. ‘Dietary Immunomodulatlon: Benef. Effects on Oncogenesis and Tumor Growth”, Crit. Care Med., 1990. Fryburg D, ‘NG-Monomethyl-L-Arginine Inhibits the Blood Flow but not the Insulin-like Response of Forearm Muscle to IFG-1.: Possible Role of Nitric Oxide in Muscle Protein Synthesis” J. of Clin Invest., 1996. Panza, Julio A, M.D., and Cannon III, Richard 0., M.D. edited by, Endothelium. Nitric Oxide, and Arteriosclerosis. 1999. Korbut,R., PhD., Bieron, Krzysztof, Bieron, M.D., Gryglewski, M.D.,D.Sc., N.Copernicus Univ, School of Med,. “Effect of L-Arginine on Plasminogen-Activator Inhibitor in Hypertensive Patients with Hypercholesterolemia, ‘New England J. of Med., Jan. 1993. Chowienczyk, Pd., Watts, G.F., Cockcroft, J.R., Ritter, J.M., ‘Impaired Endothelium-Dependent Vasodilatation of Forearm Resistance Vessels in Hypercholesterolemia”, ‘The Lancet’, 1992. Balch, J. M.D., Balch, P., C.N.C., Prescription for Nutritional Healing, 1997.

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Glossary

Column

Amino Acids - Are the building blocks of protein. Your body is primarily made of protein.  And protein in turn, is made up of chains of amino acids What distinguishes all amino acids is that they all have a group, (amine group), made of 1 atom of nitrogen & 2 atoms of hydrogen. (NH₂)

Free-Form Amino Acids - Individual amino acids that are  unattached to each other or anything else & therefore able to be immediately absorbed into the blood stream with no digestion necessary. Since, unlike proteins, free-form amino acids require absolutely no digestion, they can be absorbed by anyone no matter how old they may be or the condition of their digestive system.  Also, unlike proteins, free-form amino acids can be taken on an empty stomach such as right before a workout.  Whereas proteins have to have a mass of food sufficient to stimulate the release of digestive juices. This is why most protein supplements are presented as blender drinks.  Free-form amino acids are not to be confused with so-called "predigested protein."

Negative nitrogen balance - The condition of excreting more amino acids & protein than one is taking in. This makes it difficult to maintain ones body since the body's tissues are mainly made of protein & amino acids which require constant maintenance & repair.

Precursors - the substance from which another substance is made.

Protein - Chains of some combination of the 20 so-called "proteogenic" amino acids. (proteogenic means to generate protein). In other words their are only 20  amino acids from which all proteins in all organic life both animal & vegetable are made. Not all 20 are in every protein, but nothing else but some portion of the 20 proteogenic amino acids in repetitive long chains often approx. 100,000 amino acids long are what all proteins in all life are made from.

Secretalogical cells - Cells that secrete hormones.